Group 3

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Group 3

Group 3 biological agent can cause severe human disease and present a serious hazard to workers; it may present a risk of spreading to the community, but there is usually effective prophylaxis or treatment available

Fig. SARS-CoV-2 - structure (www.scientificanimations.com).

A - Possible allergic effects

D - List of workers exposed to this biological agent to be kept for more than 10 years after the end of last known exposure

T - Toxin production

V - Effective vaccine available and registered within the EU

⁽¹⁾	Classification according to WHO Global Action Plan to minimize poliovirus facility-associated risk after type-specific eradication of wild polioviruses and sequential cessation of oral polio vaccine use.
*	Member States are to ensure that all viruses which have already been isolated in humans and which have not been assessed and allocated in this Annex are classified in group 2 as a minimum, except where Member States have proof that they are unlikely to cause disease in humans.
**	Biological agents may present a limited risk of infection for workers because they are not normally infectious by the airborne route

PRION DISEASE AGENTS (a) Recommended for work involving direct contact with these agents. VIRUSES (a) Tick-borne encephalitis

Viruses have been listed according to their order (O), family (F) and genus (G).

BACTERIA	Notes
Bacillus anthracis
Brucella abortus
Brucella canis
Brucella inopinata
Brucella melitensis
Brucella suis
Burkholderia maleli (Pseudomonas mallei)
Burkholderia pseudomallei (Pseudomonas pseudomallei)	D
Chlamydia psittaci (Chlamydophila psittaci) (avian strains)
Coxiella burnetii
Escherichia coli, szczepy verocytotoksyczne lub enterotoksyczne (np.: 0157: H7, 0124 lub 0123)	* T
Francisella tularensis subsp. tularensis
Mycobacterium africanum	V
Mycobacterium bovis (Prątek bydlęcy)	V
Mycobacterium caprae (Mycobacterium tuberculosis subsp. caprae)
Mycobacterium leprae
Mycobacterium microti	*
Mycobacterium pinnipedii
Mycobacterium tuberculosis (Prątek gruźlicy ludzkiej)	V
Mycobacterium ulcerans	*
Orientia tsutsugamushi (Rickettsia tsutsugamushi)
Rickettsia africae
Rickettsia akari	*
Rickettsia australis
Rickettsia conorii
Rickettsia heilongjiangensis	*
Rickettsia japonica
Rickettsia typhi
Rickettsia prowazekii
Rickettsia rickettsii
Rickettsia sibirica
Salmonella Typhi	V , *
Shigella dysenteriae (Typ 1) (Pałeczka czerwonki)	T, *
Yersinia pestis
VIRUSES
Bunyavirales (O)
Hantaviridae (F)
Orthohantavirus (G)
Andes (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS])
Bayou orthohantavirus
Black Creek Canal orthohantavirus
Caño Delgadito orthohantavirus
Choclo orthohantavirus
Dobrava-Belgrade orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])
El Moro Canyon orthohantavirus
Hantaan orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])
Hantawirus Laguna Negra orthohantavirus
Seoul orthohantavirus (Hantavirus species causing Haemorrhagic Fever with Renal Syndrome [HFRS])
Sin Nombre orthohantavirus (Hantavirus species causing Hantavirus Pulmonary Syndrome [HPS])
Peribunyaviridae (F)
Orthobunyavirus (G)
Oropouche orthobunyavirus
Phenuiviridae (F)
Phlebovirus
Rift Valley fever phlebovirus
SFTS phlebovirus (Severe Fever with Thrombocytopenia Syndrome-Virus)
Herpesvirales (O)
Herpesviridae (F)
Simplexvirus (G)
Macacine alphaherpesvirus 1 (Herpesvirus simiae, Herpes B virus)
Rhabdoviridae (F)
Lyssavirus (G)
Australian bat lyssavirus	V , *
Duvenhage lyssavirus	V , **
European bat lyssavirus 1	V , **
European bat lyssavirus 2	V , **
Lagos lyssavirus	**
Mokola lyssavirus
Rabies lyssavirus	V , **
Nidovirales (O)
Coronaviridae (F)
Betakoronavirus (G)
Severe acute respiratory syndrome-related coronavirus (SARS-virus)
Middle East respiratory syndrome coronavirus (MERS-virus)	(10)
Pikornavirales (O)
Picornaviridae (F)
Enterovirus (G)
Poliovirus, type 2⁽¹⁾	V
Hepatovirus (G)
Unassigned (O)
Arenaviridae (F)
Mammarenavirus (G)
Flexal mammarenavirus
Whitewater Arroyo mammarenavirus
Hepadnaviridae (F)
Ortohepadnawirus (G)
Hepatitis B virus	V, D, **
Flaviviridae (F)
Flavivirus (G)
Dengue virus
Japanese encephalitis virus	V
Kyasanur Forest disease virus	V
Louping ill virus	**
Murray Valley encephalitis virus (Australia encephalitis virus)
Omsk haemorrhagic fever virus
Powassan virus
Rocio virus
St. Louis encephalitis virus
Tick-borne encephalitis virus
Absettarov virus
Hanzalova virus
Hypr virus
Kumlinge virus
Negishi virus
Russian spring-summer encephalitis (a)	V
Tick-borne encephalitis virus Central European subtype	V, **
Tick-borne encephalitis virus Far Eastern Subtype
Tick-borne encephalitis virus Siberian subtype	V
Wesselsbron virus
West Nile fever virus
Yellow fever virus	V
Hepacivirus (G)
Hepacivirus C (Hepatitis C virus)	D, **
Orthomyxoviridae (F)
Influenzavirus A (G)
Highly Pathogenic Avian Influenza Viruses HPAIV (H5), e.g. H5N1
Highly Pathogenic Avian Influenza Viruses HPAIV (H7), e.g. H7N7, H7N9
Influenza A virus A/New York/1/18 (H1N1) (Spanish flu 1918)
Influenza A virus A/Singapore/1/57 (H2N2)
Low Pathogenic Avian Influenza Virus (LPAI) H7N9
Poxviridae (F)
Orthopoxvirus (G)
Monkeypox virus	V
Retroviridae (F)
Deltaretrovirus (G)
Primate T-lymphotropic virus 1 (Human T-cell lymphotropic virus, type 1)	D, **
Primate T-lymphotropic virus 2 (Human T-cell lymphotropic virus, type 2)	D, **
Lentivirus (G)
Human immunodeficiency virus 1	D, **
Human immunodeficiency virus 2	D, **
Togaviridae (F)
Alphavirus (G)
Cabassou virus
Eastern equine encephalomyelitis virus	V
Chikungunya virus	**
Everglades virus	**
Mayaro virus	**
Mucambo virus	**
Ndumu virus	**
Tonate virus	**
Venezuelan equine encephalomyelitis virus	V
Western equine encephalomyelitis virus	V
PARASITES
Balamuthia mandrillaris
Echinococcus granulosus	**
Echinococcus multilocularis	**
Echinococcus oligarthrus	**
Echinococcus vogeli	**
Leishmania braziliensis	**
Leishmania donovani	**
Leishmania guyanensis (Viannia guyanensis)	**
Leishmania infantum (Leishmania chagasi)	**
Leishmania panamensis (Viannia panamensis)	**
Naegleria fowleri
Plasmodium falciparum	**
Plasmodium knowlesi	**
Taenia solium	**
Trypanosoma brucei rhodesiense	**
Trypanosoma cruzi	**
FUNGI
Blastomyces dermatitidis (Ajellomyces dermatitidis)
Blastomyces gilchristii
Cladophialophora bantiana (Xylohypha bantiana, Cladosporium bantianum, trichoides)
Cladophialophora modesta
Coccidioides immitis	A
Coccidioides posadasii	A
Histoplasma capsulatum
Histoplasma capsulatum var. farciminosum
Histoplasma duboisii
Paracoccidioides brasiliensis	A
Paracoccidioides lutzii
Rhinocladiella mackenziei
PRION DISEASE AGENTS
Agent of Creutzfeldt-Jakob disease	D (a), *
Variant Agent of Creutzfeldt-Jakob disease	D (a), **
Agent of Bovine Spongiform Encephalopathy (BSE) and other related animal TSEs	D (a), **
Agent of Gerstmann-Sträussler-Scheinker syndrome	D (a), **
Agent of Kuru	D (4), **

Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy

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